4-Hydroxytamoxifen是tamoxifen的活性代謝產(chǎn)物，是一種選擇性的雌激素受體調(diào)節(jié)分子，在乳腺癌的治療和化學(xué)療法中應(yīng)用廣泛。
NVP-HSP990產(chǎn)品描述：NVP-HSP990(HSP990) is an orally bioavailable inhibitor of Hsp90(IC50=13 nM; Hsp90α) with potential antineoplastic activity. IC50 value: 13 nM(Hsp90α) [1] Target: Hsp90 inhibitor in vitro: NVP-HSP990 triggered apoptosis in a panel of human multiple myeloma cells, induced cell-cycle arrest, PARP cleavage, downregulation of client proteins, the inability to reactivate phospho-STAT3 following exogenous IL-6 stimulation, and it synergized with azacytidine and bortezomib in cell lines and primary multiple myeloma samples [2]. Exposure of MM cells to a combination of NVP-HSP990 and either melphalan or histone deacetylase (HDAC) inhibitors caused synergistic inhibition of viability, increased induction of apoptosis, and was able to overcome the primary resistance of the cell line RPMI-8226 to HSP90 inhibition [3]. in vivo: HSP990 was given to control mice every 3 days for 14 days at close to the maximum tolerated dose, which was most likely to reveal any effect on phototransduction machi


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Purity:98%
MWt:387.5140
Formula:C26H29NO2
SMILES:CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3.[(Z)]
Pathway:Autophagy; Cell Cycle/DNA Damage;
Mechanisms:Autophagy; CRISPR/Cas9;
Research Area:Cancer
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